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HIV-associated immune dysfunction and delayed pubertal development in a cohort of young hemophiliacs. Hemophilia

E M Mahoney1, S M Donfield, C Howard

  • 1Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA. eliz@hp3.eushc.org

Journal of Acquired Immune Deficiency Syndromes (1999)
|July 31, 1999
PubMed

As part of the Hemophilia Growth and Development Study (HGDS), we investigated the relationship between HIV-associated immune dysfunction and delayed pubertal development in a cohort of 333 boys and adolescents with moderate or severe hemophilia who were between the ages of 6 and 19 years at study entry in 1989. Sixty-two percent of the cohort was infected with HIV in the late 1970s and early 1980s through exposure to contaminated clotting factor concentrates. The cohort was observed during follow-up at 6-month intervals; measurements taken at each follow-up visit included Tanner stage and CD4+ cell count. This analysis of data from the first 4 years of follow-up revealed statistically significant delays in pubertal development associated with increasing levels of immune dysfunction. Our results emphasize the importance of following pubertal development in HIV-infected adolescent boys since delays in maturation may reflect underlying disease progression.

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