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Effect of diethylstilbestrol on reproductive function.
1Department of Gynecology and Obstetrics, The Cleveland Clinic Foundation, Ohio 44195, USA. goldbej@cesmtp.ccf.org
Fertility and Sterility
|July 31, 1999
Summary
Women exposed to diethylstilbestrol (DES) in utero face reduced fertility and higher risks of pregnancy complications. Understanding these effects is crucial for patient counseling and managing reproductive health outcomes.
Area of Science:
- Reproductive medicine
- Endocrinology
- Obstetrics and Gynecology
Background:
- Diethylstilbestrol (DES) is a synthetic estrogen previously prescribed to prevent pregnancy loss.
- In utero exposure to DES has been linked to various reproductive abnormalities.
Purpose of the Study:
- To review the impact of in utero diethylstilbestrol (DES) exposure on müllerian development.
- To assess the subsequent effects on female reproductive function.
Main Methods:
- Literature review of studies on DES and reproductive function.
- Identification of studies through MEDLINE database and manual bibliography searches.
Main Results:
- In utero DES exposure is associated with decreased fertility.
- Increased rates of ectopic pregnancy, spontaneous abortion, and preterm delivery observed.
Conclusions:
- Understanding reproductive outcomes in DES-exposed women is vital for patient counseling.
- Informed counseling can guide patients on risks and available treatment options.