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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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Related Experiment Video

Updated: Jul 23, 2026

Cochlear Implantation in the Guinea Pig
09:56

Cochlear Implantation in the Guinea Pig

Published on: June 15, 2018

Cochlear implants in the geriatric population: benefits outweigh risks.

C A Buchman1, M J Fucci, W M Luxford

  • 1House Ear Clinic, Los Angeles, USA.

Ear, Nose, & Throat Journal
|August 3, 1999
PubMed
Summary

Cochlear implantation offers effective hearing rehabilitation for elderly individuals with severe to profound hearing loss. Outcomes in older adults are comparable to younger patients, with excellent audiologic and quality-of-life results.

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Performing Repeated Intraoperative Impedance Telemetry Measurements during Cochlear Implantation
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Last Updated: Jul 23, 2026

Cochlear Implantation in the Guinea Pig
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Published on: June 15, 2018

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
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Performing Repeated Intraoperative Impedance Telemetry Measurements during Cochlear Implantation
06:54

Performing Repeated Intraoperative Impedance Telemetry Measurements during Cochlear Implantation

Published on: August 4, 2023

Area of Science:

  • Otolaryngology
  • Audiology
  • Geriatrics

Background:

  • Cochlear implantation is a standard treatment for severe to profound hearing loss.
  • Unique challenges exist for elderly patients, including age-related auditory changes and comorbidities.

Purpose of the Study:

  • To evaluate the efficacy and safety of cochlear implantation in elderly patients.
  • To identify factors influencing outcomes in this demographic.

Main Methods:

  • Review of audiologic and quality-of-life outcomes in patients over 65.
  • Analysis of perioperative medical and surgical considerations.

Main Results:

  • Outcomes in elderly patients are comparable to younger adults.
  • Excellent audiologic gains and improved quality of life were observed.
  • Safe surgical insertion with minimal complications is achievable.

Conclusions:

  • Cochlear implantation is a safe and effective hearing rehabilitation option for the elderly.
  • Careful perioperative management is crucial for successful outcomes.
  • Age is not a barrier to achieving significant benefits from cochlear implants.