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Leukemic macrocheilia associated with chronic lymphocytic leukemia
1Department of Dermatology, Yonsei University Wonju College of Medicine, Korea.
Cutis
|August 4, 1999
Summary
Specific cutaneous infiltrates in chronic lymphocytic leukemia (CLL) are rare, especially oral mucosa involvement. This case highlights leukemic macrocheilia as an early, preceding sign of CLL diagnosed years later.
Area of Science:
- Oncology
- Dermatology
- Hematology
Background:
- Cutaneous infiltrates in chronic lymphocytic leukemia (CLL) are uncommon, typically presenting as tumors or nodules on the face, scalp, and trunk.
- Oral mucosal involvement in CLL is exceptionally rare, posing diagnostic challenges.
Observation:
- A patient presented with leukemic macrocheilia, characterized by enlarged lips.
- This oral manifestation preceded the diagnosis of CLL by three years.
- The presentation mimicked a tumor or nodule, consistent with rare cutaneous infiltrates.
Findings:
- Leukemic macrocheilia can be an extremely rare presenting sign of chronic lymphocytic leukemia.
- The oral mucosa can be involved in CLL, albeit infrequently.
- Cutaneous manifestations of CLL may precede systemic diagnosis.
Implications:
- Clinicians should consider rare oral presentations in the differential diagnosis of unexplained lip enlargement.
- Early recognition of unusual CLL manifestations may lead to earlier diagnosis and treatment.
- This case underscores the diverse and sometimes atypical clinical spectrum of chronic lymphocytic leukemia.