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Autonomic dysreflexia
1Spinal Injuries Unit, Institution of Clinical Neuroscience, University of Göteborg, Sweden.
Spinal Cord
|August 4, 1999
Summary
Autonomic dysreflexia (AD) is a serious condition in spinal cord injury (SCI) patients above T6. This review covers AD
Area of Science:
- Neurology
- Physiology
- Rehabilitation Medicine
Background:
- Autonomic dysreflexia (AD) is a potentially life-threatening condition complicating spinal cord injury (SCI) above the T6 level.
- New insights into pathogenic mechanisms and metabolic effects of AD are emerging.
- Existing treatments focus on removing triggers, but new mechanisms and treatments are being explored.
Purpose of the Study:
- To provide a comprehensive review of autonomic dysreflexia (AD) in spinal cord injury (SCI).
- To discuss clinical aspects, pathogenic mechanisms, incidence, prevalence, and triggering factors of AD.
- To explore current and future treatment strategies for AD.
Main Methods:
- Literature review of clinical aspects, pathophysiology, epidemiology, and treatment of autonomic dysreflexia (AD).
- Synthesis of recent data on pathogenic mechanisms and metabolic effects.
- Discussion of symptomatic and specific treatment modalities.
Main Results:
- AD is associated with significant morbidity, including cerebral hemorrhage, seizures, and pulmonary edema.
- Triggers for AD are diverse and can be influenced by new treatments.
- Pathophysiology and metabolic effects require further investigation.
Conclusions:
- A precise definition and deeper understanding of AD pathophysiology are needed.
- Further research on incidence, prevalence, and novel therapeutic approaches is essential.
- Effective management of AD requires addressing both known and emerging triggers and mechanisms.