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Related Experiment Videos

Familial versus sporadic longevity and MHC markers.

N Henon1, M Busson, C Dehay-Martuchou

  • 1Jean Dausset Foundation, Paris, France.

Journal of Biological Regulators and Homeostatic Agents
|August 5, 1999
PubMed
Summary

The human leukocyte antigen (HLA) DR11 allele is more frequent in nonagenarians from long-lived families, suggesting a role in familial longevity. This finding highlights the heterogeneity of aging and the immune system's involvement.

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Area of Science:

  • Immunogenetics
  • Gerontology
  • Human Genetics

Background:

  • The genetic factors influencing human longevity are complex and not fully understood.
  • Human Leukocyte Antigen (HLA) genes play a crucial role in immune response and have been implicated in various age-related conditions.
  • Investigating HLA polymorphism in extremely aged populations can provide insights into the genetic basis of longevity.

Purpose of the Study:

  • To investigate the association between HLA (Human Leukocyte Antigen) Class I and Class II allele frequencies and longevity in elderly populations.
  • To compare HLA polymorphism in centenarians and nonagenarians with familial longevity against a younger control group.
  • To explore the potential protective role of specific HLA alleles in exceptional aging.

Main Methods:

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  • Genotyping of HLA-A, HLA-B, and HLA-DRB1 alleles in elderly cohorts (centenarians and nonagenarians) and a control group.
  • Statistical analysis to compare allele frequencies between groups.
  • Assessment of haplotype sharing in familial nonagenarian sibling pairs.

Main Results:

  • A significantly increased frequency of the HLA-DRB1*11 allele was observed in familial nonagenarians (18.3%) compared to controls (10%) and sporadic centenarians (11.8%).
  • Rare HLA Class I alleles (A30, B70) showed significant differences from controls after statistical correction.
  • No distortion in Mendelian sharing of haplotypes was found in familial nonagenarian sibling pairs.

Conclusions:

  • The study suggests that the HLA-DRB1*11 allele may be associated with familial longevity, potentially through a protective effect in presenting immunogenic peptides.
  • Longevity is heterogeneous, with genetic factors like specific HLA alleles contributing to exceptional aging, particularly in familial forms.
  • The findings support the role of the immune system, specifically HLA genetics, in influencing lifespan and healthy aging.