[Brain monoaminoxidase during late ontogenesis in rats genetically predisposed to pendulum-like movements]

N N Voĭtenko¹, N N Barykina, V G Kolpakov

¹Institute of Cytology and Genetics, Siberian Branch of the Russian Acad.Sci., Novosibirsk, Russia.

Voprosy Meditsinskoi Khimii

|August 5, 1999

Abstract:

Rats genetically predisposed (PM+) and non-predisposed (PM-) to pendulum movement (spontaneous nystagm) were studied at different age. In old PM+ and PM- rats the brain MAO-A activity did not differ, unlike between young PM+ and PM- rats. In old PM+ and PM- rats, brain stem MAO-A activity was higher than in young ones. Actinomycin D lowered brain stem MAO-A activity in PM+ and PM- rats. In the absence of actinomycin D, stress elevated MAO-B activity in the brain stem of PM- rats, and a preliminary actinomycin D administration prevent the MAO-B activating effect of stress. Possible differences in MAO-A and MAO-B regulation at transcription level in PM+ and PM- are discussed.

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Abstract:

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