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Synthesis of 5'-thioalkyl, sulfoxide and sulfone pyrimidine nucleosides
L A Agrofoglio1, F Girard, F Fleury
1I.C.O.A., associé au CNRS, Faculté des Sciences, Orléans-France.
Nucleosides & Nucleotides
|August 5, 1999
Abstract:
The preparation of 5'-thioalkyl, sulfoxide and sulfone pyrimidine nucleosides is [4-11] is described. The key steps of this synthesis are the nucleophilic displacements of a chlorine by a thioalkyl sodium salt or the direct introduction of the thioalkyl group under Mitsunobu conditions.