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Synthesis and receptor affinity of polysubstituted adenosines
S Vittori1, E Camaioni, S Costanzi
1Dipartimento di Scienze Chimiche, Università di Camerino, Italy.
Nucleosides & Nucleotides
|August 5, 1999
Abstract:
In a search for potent and selective adenosine agonists it has been found that 2-hexynyladenosine-5'-N-ethyluronamide (HENECA) displays high affinity at rat A2A receptor combined with a good A2A vs A1 selectivity. The finding that HENECA shows good affinity also for A3 receptors prompted us to investigate the effect of various substituents in different positions of this molecule.