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Synthetic studies on 2'-substituted-4'-thiocytidine derivatives as antineoplastic agents
Y Yoshimura1, M Endo, K Kitano
1Biochemicals Division, Yamasa Corporation, Chiba, Japan. chem2yms@choshinet.or.jp
Nucleosides & Nucleotides
|August 5, 1999
Abstract:
As potential antineoplastic agents, we have synthesized 4'-thioFAC and 4'-thiocytarazid by developing an alternative synthetic method. 4'-ThioFAC showed potent antineoplastic activities in vivo as well as in vitro.