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CycloSal-2'-ara(ribo)-fluoro-2',3'-dideoxyadenosine monophosphates--an effort to solve the structure-activity
C Meier1, T Knispel, V E Marquez
1Institut für Organische Chemie, Universität Hamburg, Germany.
Nucleosides & Nucleotides
|August 5, 1999
Abstract:
Novel lipophilic cycloSal-triesters 3 and 4 from the ara- and ribo-configurated 2'-fluorinated ddAs 1 and 2, respectively, were prepared. The title compounds 3 and 4 delivered the corresponding monophosphates and thus, increasing the bioactivity or convert a formerly inactive compound into a RT inhibitor.