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Effects of cycloSal-d4TMP derivatives in H9 cells with induced AZT resistance phenotype
B Gröschel1, C Meier, R Zehner
1Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt/M., Germany.
Abstract:
Cytotoxic and antiretroviral activity of cycloSal-d4TMP derivatives were tested in a new AZT-resistant H9 cell subline (H9rAZT250). The results showed, that cycloSal-d4TMP derivatives overcame resistance of HIV-1 to d4T in H9rAZT250 cells, which exert decreased thymidine kinase (TK) gene expression.