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C cells in normal thyroid aspirates.

M A de Lima1, B M Santos, F S Tiveron

  • 1Faculty of Medicine, Triângulo Mineiro, Uberaba, Minas Gerais, Brazil. lima@mednet.com.br

Acta Cytologica
|August 5, 1999
PubMed
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This study quantifies C cells in normal thyroid aspirates, finding them in all specimens. Results show C cells are more common in the upper and middle thirds, particularly on the right side, and rare in the isthmus.

Area of Science:

  • Endocrinology
  • Histopathology
  • Cytopathology

Background:

  • C cells, also known as parafollicular cells, are endocrine cells found in the thyroid gland.
  • These cells produce calcitonin, a hormone involved in calcium regulation.
  • Quantifying C cells in normal thyroid tissue is crucial for understanding thyroid pathology.

Purpose of the Study:

  • To establish normal C cell counts in thyroid aspirates.
  • To determine the distribution of C cells within the normal thyroid gland.
  • To provide a baseline for diagnosing C cell hyperplasia and related conditions.

Main Methods:

  • Analysis of thyroid aspirate smears from 18 individuals without thyroid disease.
  • Aspiration of five samples from each lateral lobe (upper, middle, lower thirds) and the isthmus.

Related Experiment Videos

  • Immunohistochemical staining using an anticalcitonin monoclonal antibody.

    • Main Results:

    • C cells were detected in all analyzed thyroid aspirates.
    • The number of C cells per gland ranged from 3 to 19.
    • C cells were predominantly found in the right lobe (53.4%) and left lobe (42.8%), with fewer in the isthmus (3.7%).
    • Distribution varied by lobe third, with higher concentrations in the upper and middle thirds.

    Conclusions:

    • Normal thyroid aspirates contain detectable C cells, confirming histological findings.
    • The distribution pattern (more frequent in upper/middle thirds, right side; rare in isthmus) is established.
    • This method offers a rapid, precise, and minimally invasive approach for diagnosing C cell hyperplasia and monitoring conditions like Hashimoto's thyroiditis and goiter.