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The in vivo and in vitro comparative nephrotoxicity of cefazolin and gentamicin
O Yilmaz1, M Cabalar, S Ozbilgin
1Department of Pharmacology and Toxicology, Yuzuncu Yil University, Van, Turkey.
Abstract:
Biochemical, histopathological and cell culture evaluations compared the nephrotoxicity of cefazolin with that of gentamicin. New Zealand rabbits were dosed with 250 mg cefazolin/animal i.m. twice daily, 3 mg gentamicin/kg i.m. twice daily, or 0.9% NaCl solution for 10 d. The rabbits in drug-treated groups had necrosis of proximal kidney tubules and elevated urinary-gamma glutamyl transferase (uGGT) levels. The results of the histopathological examinations, uGGT analyses and effects in cell culture indicated the nephrotoxicities of both antibiotics were similar.
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