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[An experimental study on effect of atrial natriuretic peptide on intraocular pressure of white rabbits]
Objective:
To study the therapeutic effect of atrial natriuretic peptide (ANP) on glaucoma.
Methods:
Various doses of ANP were injected subconjunctivally in albino rabbits, and their effects on intraocular pressures (IOPs) were observed.
Results:
The IOPs were significantly decreased by the subconjunctival injection of 20, 30, 40 micrograms of ANP, and with a dose of 40 micrograms, the maximum effect of IOP lowering of 0.88-0.15 kPa maintaining for the longest time 7.5 hours was obtained. Generally, one hour after the injection, the maximum effect could be seen. A dose-effect relationship that is the degree of the reduction of IOP increasing with the dose increase of ANP could be observed.
Conclusion:
This study indicates that ANP might play an effective therapeutic role in glaucoma.