[An observation on early morphological changes in retinal microvascular vessels in diabetic rats]

¹Department of Ophthalmology, General Hospital of PLA, Beijing.

[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology

|May 1, 1997

Abstract

Objectives:

To investigate the morphological changes of retinal microcirculation in streptozotocin (STZ)-diabetic rats and the contribution of leukocyte to diabetic retinopathy (DR).

Methods:

12 male Wistar rats were randomly divided into normal control group, 3 month group and 6 month group of STZ-diabetic rats. Each group was perfused with 4% paraformaldehyde and fixed. Rat retina digest preparations were observed by light microscope, and the number of pericyte was counted.

Results:

The decrease of pericytes in STZ-diabetic rats was remarkable compared with that of normal control at 6 months. At 6 months, STZ-diabetic rat retinal digest preparations showed that some of the capillaries were blocked by leukocytes.

Conclusions:

After injection of STZ in rats for 6 months, early morphological changes of DR were observed, and leukocytes played a potential role in the pathogenesis of DR.

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Objectives:

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