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Oral desensitization to 5-aminosalicylic acid medications
1Walter Reed Army Medical Center, Department of Allergy & Immunology, MCHC-AL, Washington, DC 20307-5001, USA.
Background:
Although hypersensitive subjects have been desensitized to oral sulfasalazine, the feasibility of oral desensitization to the drug's active moiety, 5-aminosalicylic acid has been questioned and never been reported.
Methods:
We devised a 5-aminosalicylic acid desensitization protocol and administered the drug to two hypersensitive subjects on three occasions.
Results:
Both 5-aminosalicylic acid hypersensitive subjects were successfully desensitized without complications and were able to tolerate therapeutic doses.
Conclusion:
Despite changing the drug's properties by crushing it for incrementally increasing administration, we successfully desensitized two patients on three occasions with 5-aminosalicylic acid.