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Adult onset grape hypersensitivity causing life threatening anaphylaxis.

S K Vaswani1, B W Chang, R N Carey

  • 1Mid-Atlantic Permanente Medical Group & Johns Hopkins University School of Medicine, Baltimore, Maryland 21244, USA.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|August 7, 1999
PubMed
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Adults can develop a rare allergy to grapes, leading to severe anaphylaxis. This case highlights late-onset food hypersensitivity to Vitis vinifera, emphasizing the need for awareness.

Area of Science:

  • Food allergy research
  • Clinical immunology
  • Adverse drug reactions

Background:

  • Adverse food reactions are less common in adults compared to children.
  • Adult-onset hypersensitivity to grapes (Vitis vinifera) is rare and previously unreported.

Observation:

  • A 28-year-old woman presented with anaphylaxis after consuming white grapes.
  • She experienced urticaria, angioedema, and dizziness, consistent with a severe allergic reaction.
  • Previous similar episodes after grape ingestion were noted.

Findings:

  • Positive grape prick skin tests with a pseudopod reaction.
  • Elevated total serum IgE levels (1918 ng/mL).
  • Weakly positive grape-specific IgE by modified RAST, negative by Cap System.

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Implications:

  • Hypersensitivity to common fruits like grapes can manifest later in life.
  • Late-onset food allergies can cause life-threatening anaphylaxis.
  • This case underscores the importance of considering food allergies in adult-onset anaphylaxis.