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Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
14:19

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Published on: June 29, 2013

Intrauterine growth retardation and long-term effects on growth

D Botero1, F Lifshitz

  • 1Miami Children's Hospital, Department of Medical Education, Florida 33155, USA.

Current Opinion in Pediatrics
|August 10, 1999
PubMed

Insights

Intrauterine growth retardation (IUGR) leads to significant health issues and growth disabilities. Recent studies explore human growth hormone and genetic factors to improve outcomes for affected children.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Genetics

Background:

  • Intrauterine growth retardation (IUGR) is a prevalent condition associated with significant morbidity and mortality.
  • Long-term growth disabilities are a critical sequela of IUGR, impacting final height potential.
  • Emerging evidence links IUGR causes to adult-onset disorders.

Purpose of the Study:

  • To review the impact of intrauterine growth retardation (IUGR) on child development.
  • To evaluate recent trials using human growth hormone for IUGR management.
  • To discuss advances in fetal growth, genetics, and endocrine factors related to IUGR.

Main Methods:

  • Review of recent clinical trials involving human growth hormone therapy in IUGR patients.
  • Analysis of epidemiological and clinical data on IUGR causes.
  • Examination of genetic and endocrine factors influencing fetal growth.

Main Results:

  • Human growth hormone therapy shows potential in maximizing growth and final height in children with IUGR.
  • Recent advances in understanding genetic and endocrine factors are crucial for fetal growth.
  • IUGR etiology is increasingly linked to adult-onset conditions.

Conclusions:

  • Intrauterine growth retardation (IUGR) requires comprehensive management strategies focusing on long-term growth.
  • Human growth hormone offers a promising therapeutic avenue for improving growth outcomes.
  • Further research into IUGR's origins and long-term health implications is essential.

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