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Related Experiment Videos

ATF3 and stress responses.

T Hai1, C D Wolfgang, D K Marsee

  • 1Department of Medical Biochemistry, Ohio State University, Columbus 43210, USA. hai.2@osu.edu

Gene Expression
|August 10, 1999
PubMed
Summary
This summary is machine-generated.

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Activating transcription factor 3 (ATF3) is a stress-inducible protein. Its role in cellular stress responses is complex, potentially activating or repressing genes depending on cellular context.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Genetics

Background:

  • The ATF/CREB family comprises over 10 proteins with basic region-leucine zipper (bZip) DNA-binding domains.
  • Protein nomenclature within this family has been historically complex due to multiple names for identical or homologous cDNA clones.
  • Understanding these proteins and their interactions is crucial for deciphering cellular signaling pathways.

Purpose of the Study:

  • To review the roles of Activating Transcription Factor 3 (ATF3) in cellular stress responses.
  • To clarify the nomenclature and relationships within the ATF/CREB family of transcription factors.
  • To explore the induction mechanisms and functional consequences of ATF3 expression under stress.

Main Methods:

  • Literature review of studies on ATF/CREB family members and ATF3.

Related Experiment Videos

  • Analysis of experimental data on ATF3 mRNA induction by various stress signals in animal models and cell cultures.
  • Examination of in vitro transcription assays and preliminary experimental results regarding ATF3 function.

    • Main Results:

    • ATF3 mRNA levels significantly increase in response to diverse stress signals, including ischemia, wounding, and genotoxic agents.
    • The JNK/SAPK pathway is implicated in ATF3 induction, with IL-6 and p53 playing roles under specific conditions.
    • ATF3 can act as a transcriptional repressor as a homodimer but may activate transcription when forming heterodimers, suggesting context-dependent functions.

    Conclusions:

    • ATF3 is a key player in cellular stress responses, with its expression significantly upregulated by various stressors.
    • The precise physiological significance of ATF3 induction remains largely unclear, necessitating further investigation.
    • ATF3's dual role as a potential transcriptional activator or repressor highlights its complex regulatory functions in different cellular contexts.