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Phenothiazine-induced acute colitis: a positive rechallenge case report
M C Filloux1, K Maréchal, H Bagheri
1Service Médico-Psychologique Régional, Maison d'Arrêt St Michel, Faculté de Médecine, Hôpitaux de Toulouse, France.
Clinical Neuropharmacology
|August 12, 1999
Summary
Phenothiazine medications can cause a severe bowel condition called necrotizing colitis. This adverse drug reaction was confirmed in a patient through drug rechallenge, highlighting a potential risk.
Area of Science:
- Gastroenterology
- Clinical Pharmacology
- Toxicology
Background:
- Phenothiazines are a class of drugs with antipsychotic and antiemetic properties.
- Adverse drug reactions associated with phenothiazine use can manifest in various organ systems.
Observation:
- A 41-year-old male patient developed necrotizing colitis.
- The patient had been administered phenothiazine medication.
- Symptoms of colitis resolved upon discontinuation of the drug.
Findings:
- A positive rechallenge with a different phenothiazine agent confirmed the drug-induced etiology.
- Necrotizing colitis is a rare but serious adverse drug reaction linked to phenothiazines.
Implications:
- This case underscores the importance of considering phenothiazines in the differential diagnosis of severe colitis.
- Further investigation into the specific mechanisms of phenothiazine-induced gastrointestinal toxicity is warranted.
- Clinicians should be vigilant for gastrointestinal adverse events in patients receiving phenothiazine therapy.