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Can winter depression be prevented by Ginkgo biloba extract? A placebo-controlled trial
O Lingaerde1, A R Føreland, A Magnusson
1Department of Research and Education, Aker Hospital, Oslo, Norway.
Objective:
The aim was to test the hypothesis that the Ginkgo biloba extract PN246, in tablet form (brand name Bio-Biloba), may prevent the symptoms of winter depression (WD) in patients with seasonal affective disorder (SAD).
Method:
A total of 27 SAD patients were randomized to receive double-blind placebo or Bio-Biloba for 10 weeks or until they developed symptoms of WD, starting in a symptom-free phase about 1 month before expected WD symptoms. An extended Montgomery-Asberg Depression Rating Scale was completed before and immediately after termination of medication. The patients also self-rated some key symptoms on a visual analogue scale every 2 weeks during the trial.
Results:
There were no significant differences between the treatment groups in the number of patients who developed treatment-requiring WD, or in the development of single key symptoms during the trial.
Conclusion:
We did not find that Ginkgo biloba was able to prevent the development of the symptoms of winter depression.
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