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Juvenile xanthogranuloma presenting as obstructive jaundice

P Prasil1, S Cayer, M Lemay

  • 1Centre hospitalier universitaire de Quebec, Montreal, Canada.

Journal of Pediatric Surgery
|August 12, 1999
PubMed

Insights

A 9-month-old infant with obstructive jaundice was diagnosed with juvenile xanthogranuloma. This rare condition, associated with cytomegalovirus, presented as a pancreatic mass.

Area of Science:

  • Pediatric Gastroenterology
  • Surgical Pathology
  • Pediatric Oncology

Background:

  • Obstructive jaundice in infants can stem from various causes, including rare pancreatic masses.
  • Cytomegalovirus (CMV) infections are common in infants and have been anecdotally linked to other rare conditions.

Observation:

  • A 9-month-old infant presented with obstructive jaundice and distended extrahepatic biliary tract.
  • Urine analysis was positive for cytomegalovirus.
  • A 1-cm pancreatic head mass was identified, initially concerning for malignancy.

Findings:

  • Intraoperative frozen section analysis could not definitively exclude malignancy.
  • Histopathological examination confirmed the mass as juvenile xanthogranuloma.
  • The final diagnosis was juvenile xanthogranuloma, with a noted association with cytomegalovirus.

Implications:

  • This case highlights juvenile xanthogranuloma as a rare cause of obstructive jaundice in infants.
  • The findings support a potential association between cytomegalovirus infection and juvenile xanthogranuloma.
  • Further research may elucidate the pathogenetic link between CMV and juvenile xanthogranuloma in pediatric cases.

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