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[The wasp/mosquito syndrome].

A Sabbah1, S Hassoun, M Drouet

  • 1Laboratoire d'Immuno-Allergologie, CHU, Angers.

Allergie Et Immunologie
|August 12, 1999
PubMed
Summary
This summary is machine-generated.

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This study introduces the Wasp/Mosquito syndrome, highlighting cross-reactivity between wasp venom and mosquito allergies. High rates of sensitization suggest a shared allergenic component, impacting clinical allergy assessments.

Area of Science:

  • Immunology
  • Allergology

Background:

  • Allergenic cross-reactivity between Vespula wasp venom and mosquito extracts is investigated.
  • The Wasp/Mosquito syndrome is described, detailing the association between sensitization to wasp venom and mosquito bites.

Observation:

  • A high frequency of co-sensitization was observed: 91% of individuals with mosquito-specific IgE also had Vespula wasp-specific IgE.
  • Three patient cases illustrate a clinical and biological link between mosquito and wasp venom sensitization, including anaphylaxis and persistent reactions.

Findings:

  • Direct evidence, including CAP RAST inhibition and electrophoresis, identified a common protein (42-44 kD hyaluronidase) in both wasp venom and mosquito extract.
  • Indirect evidence showed parallel increases in specific IgEs to both allergens in a desensitized patient.

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Implications:

  • The findings suggest a shared allergen, potentially hyaluronidase, responsible for cross-reactivity in Wasp/Mosquito syndrome.
  • Accurate allergy diagnosis and treatment may require testing for both wasp and mosquito sensitization.