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Related Experiment Videos

Local excision of rectal carcinoma.

M G Varma1, S J Rogers, T R Schrock

  • 1Department of Surgery, University of California, San Francisco, USA.

Archives of Surgery (Chicago, Ill. : 1960)
|August 12, 1999
PubMed
Summary

Local excision for rectal cancer shows promising outcomes when combined with chemotherapy or radiation, potentially matching radical resection results. Clinicopathologic factors did not predict recurrence in this study.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Rectal Cancer Research

Background:

  • Local excision is a treatment option for rectal cancer.
  • Predictors of recurrence after local treatment require further investigation.

Purpose of the Study:

  • To evaluate the recurrence rates and survival outcomes of rectal cancer patients treated with local excision.
  • To determine if clinicopathologic characteristics predict recurrence after local excision.

Main Methods:

  • A case series review of 58 patients who underwent local excision for rectal cancer between 1982 and 1998.
  • Median follow-up of 6 years, analyzing local and distant recurrence rates and overall survival.

Main Results:

  • The overall local recurrence rate was 14%, with no recurrences in patients receiving chemotherapy or radiation.
  • Untreated patients showed varying local recurrence rates based on tumor stage (T0-T3).
  • No clinicopathologic factor predicted local recurrence; overall survival rates were high at 1, 3, and 5 years (98%, 93%, 84%).

Conclusions:

  • Local excision combined with adjuvant therapy may yield outcomes comparable to radical resection for selected rectal cancer patients.
  • Further research into optimal treatment strategies for locally excised rectal cancers is warranted.

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