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Sarcoplasmic reticulum Ca(2+) release and muscle fatigue.
1Department of Biology, University of Portland, Portland, Oregon 97203, USA.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|August 13, 1999
Summary
Skeletal muscle fatigue involves impaired calcium (Ca2+) handling. Intense exercise reduces sarcoplasmic reticulum (SR) Ca2+ release, compromising muscle tension and highlighting the need to understand SR Ca2+ channel regulation.
Area of Science:
- Physiology
- Molecular Biology
- Exercise Science
Background:
- Skeletal muscle fatigue is linked to impaired intracellular calcium (Ca2+) handling.
- Reduced sarcoplasmic reticulum (SR) Ca2+ release during intense muscle contraction compromises muscle tension development.
Purpose of the Study:
- To provide an updated molecular understanding of the Ca2+-release process, focusing on the SR Ca2+ channel and its regulation.
- To examine mechanisms by which cellular changes during intense/prolonged activity alter SR Ca2+ release.
Main Methods:
- This review synthesizes current research on the SR Ca2+ channel, its associated proteins, and regulatory compounds.
- It analyzes proposed mechanisms for altered SR Ca2+ release post-contraction.
Main Results:
- Key factors affecting SR Ca2+ release include elevated intracellular Ca2+ concentrations.
- Alterations in metabolic homeostasis within the triadic space are implicated.
- Reactive oxygen species modify SR Ca2+ channel function.
Conclusions:
- Understanding SR Ca2+ channel regulation is crucial for elucidating skeletal muscle fatigue mechanisms.
- Cellular changes during exercise significantly impact Ca2+ handling and muscle performance.