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Antimicrobial treatment for peptic stenosis: a prospective study.
G Brandimarte1, A Tursi, L di Cesare
1Department of Internal Medicine, Cristo Re Hospital, Rome, Italy.
European Journal of Gastroenterology & Hepatology
|August 13, 1999
Summary
Helicobacter pylori eradication effectively treats peptic stenosis, resolving symptoms and stenosis in most patients. This conservative approach is recommended before considering surgery or dilation for peptic ulcer disease complications.
Area of Science:
- Gastroenterology
- Internal Medicine
- Microbiology
Background:
- Peptic stenosis, a complication of peptic ulcer disease, traditionally requires endoscopic balloon dilation or surgery.
- Emerging evidence suggests Helicobacter pylori (H. pylori) eradication may resolve peptic stenosis.
Purpose of the Study:
- To prospectively evaluate the efficacy of anti-H. pylori therapy in treating peptic stenosis in a cohort of infected patients.
Main Methods:
- A prospective study of 22 consecutive patients with benign peptic stenosis and H. pylori infection.
- Patients received H. pylori eradication therapy (omeprazole-based regimens) followed by proton-pump inhibitor treatment.
- Endoscopic controls were performed at 2, 6, and then every 6 months post-therapy.
Main Results:
- H. pylori eradication was achieved in all patients.
- Complete resolution of peptic stenosis occurred in 20/22 patients within 6 months, with symptom resolution in 2 months.
- At a median follow-up of 12.4 months, patients remained asymptomatic without recurrence.
Conclusions:
- H. pylori eradication is a safe and effective treatment for peptic stenosis.
- Conservative H. pylori eradication therapy should be attempted before resorting to endoscopic balloon dilation or surgery.