Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

PPARgamma, the ultimate thrifty gene.

J Auwerx1

  • 1LBRE, Pasteur Institute, Lille, France.

Diabetologia
|August 14, 1999
PubMed
Summary

Peroxisome proliferator-activated receptor gamma (PPARgamma) is crucial for adipogenesis and energy storage. Emerging research reveals its broader role in transcriptional control, impacting cell cycle, cancer, and inflammation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response.

The Journal of biological chemistry·2023
Same author

Estrogen-related receptor gamma regulates mitochondrial and synaptic genes and modulates vulnerability to synucleinopathy.

NPJ Parkinson's disease·2022
Same author

The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Platform.

Scientific reports·2019
Same author

Automated Platform for Long-Term Culture and High-Content Phenotyping of Single C. elegans Worms.

Scientific reports·2019
Same author

Miniaturized implantable sensors for in vivo localized temperature measurements in mice during cold exposure.

Biomedical microdevices·2015
Same author

Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass.

Obesity surgery·2012

Area of Science:

  • Molecular Biology
  • Endocrinology
  • Genetics

Background:

  • Peroxisome proliferator-activated receptor gamma (PPARgamma) has rapidly become a well-characterized nuclear receptor.
  • Initial research highlighted its critical role in adipogenesis and the "thrifty gene response" for energy storage.
  • Synthetic ligands (thiazolidinediones) showed promise as insulin-sensitizing drugs for Type II diabetes.

Purpose of the Study:

  • To review the evolving understanding of PPARgamma's functions.
  • To explore its expanded roles beyond metabolism.
  • To establish PPARgamma's significance in maintaining homeostasis.

Main Methods:

  • Literature review of PPARgamma research over the past decade.
  • Analysis of studies on adipogenesis, energy metabolism, and diabetes treatment.
  • Examination of recent findings on PPARgamma's involvement in broader cellular processes.

Main Results:

  • PPARgamma is a master regulator of adipogenesis and energy homeostasis.
  • Thiazolidinediones, PPARgamma ligands, are key in Type II diabetes treatment.
  • PPARgamma influences cell cycle control, carcinogenesis, inflammation, atherosclerosis, and immunomodulation.

Conclusions:

  • PPARgamma's role extends significantly beyond metabolism.
  • It acts as a central regulator in diverse cellular processes.
  • PPARgamma is a primary link between energy stores and whole-body homeostasis.

Related Experiment Videos