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Serum urate determines antioxidant capacity in middle-aged men - a controlled, randomized diet and exercise
M Rosell1, J Regnström, A Kallner
1Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Department of Emergency and Cardiovascular Medicine, King Gustav V Research Institute, Karolinska Institute, Stockholm, Sweden.
Journal of Internal Medicine
|August 14, 1999
Summary
Diet and exercise interventions improved cardiovascular risk factors in middle-aged men. However, these lifestyle changes did not impact serum total antioxidant capacity, though urate levels were affected.
Area of Science:
- Nutritional Science and Public Health
- Cardiovascular Disease Prevention
Background:
- Cardiovascular risk factors are prevalent in middle-aged men.
- Diet and exercise are primary lifestyle interventions for risk reduction.
- The impact of these interventions on antioxidant status requires further investigation.
Purpose of the Study:
- To investigate the effects of diet and/or exercise advice on antioxidant intake, serum urate concentration, and total antioxidant capacity (TAOC) in middle-aged men.
- To assess changes in cardiovascular risk factors following lifestyle interventions.
Main Methods:
- A 6-month randomized controlled intervention study involving 158 healthy middle-aged men with elevated cardiovascular risk factors.
- Intervention groups received advice on diet (D), exercise (E), or both diet and exercise (DE); a control group (C) received no advice.
- Measurements included dietary intake, exercise habits, serum urate (S-urate), and serum total antioxidant capacity (TAOC).
Main Results:
- All intervention groups showed improvements in dietary and exercise habits, leading to favorable changes in BMI, waist circumference, blood pressure, cholesterol, and insulin.
- Specific antioxidant intake changes included decreased alpha-tocopherol in D and E groups, and increased beta-carotene in D and DE groups. Vitamin C intake increased in the DE group.
- Serum urate levels decreased in the D group. No significant changes in TAOC were observed across any groups. S-urate was strongly correlated with TAOC and metabolic syndrome parameters.
Conclusions:
- Lifestyle modifications through diet and exercise effectively reduced cardiovascular risk factors in middle-aged men.
- These interventions did not significantly alter serum total antioxidant capacity.
- Serum urate concentration was identified as a significant determinant of total antioxidant capacity in this population.