Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

A mouse model for slowly progressive primary tuberculosis.

T Mustafa¹, S Phyu, R Nilsen

¹Centre for International Health; Department of Odontology; Broegelmann Research Laboratory, University of Bergen, Bergen, Norway.

Scandinavian Journal of Immunology

|August 14, 1999

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hyperkalaemia during a general anaesthetic in a 5-year-old domestic short-haired cat.

Australian veterinary journal·2025

Same author

Playing online videogames-more than just entertainment? A qualitative study of virtual social participation in persons with spinal cord injury.

Frontiers in rehabilitation sciences·2024

Same author

Inferring Atlantic salmon post-smolt migration patterns using genetic assignment.

Royal Society open science·2019

Same author

High-temperature deep-level transient spectroscopy system for defect studies in wide-bandgap semiconductors.

The Review of scientific instruments·2019

Same author

Ensemble methods for stochastic networks with special reference to the biological clock of Neurospora crassa.

PloS one·2018

Same author

Rare and Common Variants Conferring Risk of Tooth Agenesis.

Journal of dental research·2018

Same journal

Recent Thymic Emigrant Levels in Inborn Errors of Immunity: Is Their Diagnostic Value Greater Than We Think?

Scandinavian journal of immunology·2026

Same journal

The EBNA-1 Conundrum: Does Epstein-Barr Virus Invoke Autoimmune Pathology in a Population Subset by Poorly Purine-Loading Its Major Latency-Maintaining Transcript?

Scandinavian journal of immunology·2026

Same journal

Unsupervised Flow Cytometry Reveals a Constant Shift Towards Activated CD4<sup>+</sup> T Cell Subsets in APECED.

Scandinavian journal of immunology·2026

Same journal

RETRACTION: Interleukin-13 Induces T Helper Type 2 Immune Responses in OVA-Immunized BALB/c Mice Bearing a T Cell Lymphoma.

Scandinavian journal of immunology·2026

Same journal

Development of a Detection Method for Soluble Urokinase-Type Plasminogen Activator Receptor and Its Application in Predicting Prognosis of Severe COVID-19.

Scandinavian journal of immunology·2026

Same journal

Crohn's Disease Enteritis: Pathophysiological Mechanisms and Therapeutic Approaches.

Scandinavian journal of immunology·2026

See all related articles

Researchers developed a mouse model for slow tuberculosis progression. This model shows infection develops in three phases, with inflammation, not bacterial load, driving mortality.

Area of Science:

Immunology
Microbiology
Pathology

Background:

Tuberculosis (TB) progression from infection to disease is often slow in humans.
Existing mouse models may not fully recapitulate slow TB disease development.

Purpose of the Study:

To develop and characterize a novel mouse model for slowly progressive primary tuberculosis.
To compare this new model with a previously established model of latent Mycobacterium tuberculosis infection.

Main Methods:

B6D2F1 hybrid mice were inoculated intraperitoneally with Mycobacterium tuberculosis H37Rv.
Mice were monitored for 70 weeks, with lungs, livers, and spleens examined for bacterial load, histopathology, and antigen presence via immunohistochemistry.

Main Results:

Related Experiment Videos

The infection progressed through three distinct phases: initial asymptomatic infection with granuloma formation, a phase with stabilized bacterial counts and increased vacuolated macrophages, and a final phase of rapid decline.
Mortality in the final phase was associated with extensive lung inflammation and poorly demarcated lesions, rather than a significant increase in Mycobacterium tuberculosis CFU.

Conclusions:

The developed mouse model effectively mimics slowly progressive tuberculosis in humans.
Rapidly progressing inflammation, characterized by inflammatory infiltrates, appears to be the primary driver of mortality in this model, rather than bacterial burden alone.