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Tonometry to estimate intestinal perfusion in newborn piglets
M E Campbell1, J E Van Aerde, P Y Cheung
1Neonatal Intensive Care Unit Children's Health Centre Departments of Pediatrics University of Alberta Edmonton Canada.
Aim:
To determine the correlation between gastric intramucosal pH and superior mesenteric artery (SMA) flow in newborn piglets.
Methods:
Fourteen newborn piglets were randomly assigned to either a control or to an epinephrine group which received 0,1,2,4,0 microg/kg/min of epinephrine for 60 minutes, each dose. Gastric tonometry was performed, SMA flow was measured, and intramucosal pH and the ratio of tonometer pCO(2) over arterial pCO(2) (rCO(2)) were calculated.
Results:
Intramucosal pH decreased over time in both groups, but tended to be lower in the epinephrine group. With increasing dose of epinephrine, SMA flow decreased; this in turn increased rCO(2) (p = 0.04) with a tendency to decrease intramucosal pH (p = 0.06).
Conclusions:
Gastric tonometry may be useful in human neonates to evaluate gut ischaemia.