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Target-specific control of nicotinic receptor expression at developing interneuronal synapses in chick

P Devay1, D S McGehee, C R Yu

  • 1Columbia University, College of Physicians and Surgeons, Department of Anatomy and Cell Biology and The Center for Neurobiology and Behavior, 1051 Riverside Drive, New York, New York 10032, USA. pd11@columbia.edu

Nature Neuroscience
|August 17, 1999
PubMed

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Cholinergic Receptors: Nicotinic01:15

Cholinergic Receptors: Nicotinic

Nicotinic receptors are ligand-gated ion channels that are activated by acetylcholine and nicotine. Upon activation, they cause a rapid increase in the permeability of cells to K+, Na+, and Ca2+, followed by depolarization and excitation. They are in the autonomic ganglia, skeletal neuromuscular junction, CNS, and adrenal medulla.
There are two types of nicotinic receptors: neuromuscular (NM/NM/N1) and neuronal (NN/NN/N2). The two families differ based on their location and selectivity to...