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In Vivo Modeling of the Morbid Human Genome using Danio rerio
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In Vivo Modeling of the Morbid Human Genome using Danio rerio

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Walking through the forest of transgenic models of human disease

E E Eynon1, R A Flavell

  • 1Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA. elizabeth-eynon@yale.edu

Immunological Reviews
|August 18, 1999
PubMed

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Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...