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The design and synthesis of ALS inhibitors from pharmacophore models
1Elemento-Organic Chemistry Institute, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China.
Bioorganic & Medicinal Chemistry Letters
|August 18, 1999
Abstract:
In search of new ALS inhibitors without the previous knowledge of receptor crystal structure, DISCO module was applied to produce 3D-pharmacophore models, which provided information to design novel molecules by 3D-database searching. Then a number of molecules were synthesized. Several of them have some ALS inhibitory activities.