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[Endothelial intercellular junctions: relationship between vascular adhesion and morphogenesis].

P Huber1

  • 1CEA, Département de Biologie Moléculaire et Structurale, Grenoble, France. phuber@cea.fr

Journal De La Societe De Biologie
|August 18, 1999
PubMed
Summary
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Endothelial cell junctions maintain vascular integrity. This review details their molecular makeup and roles in vessel formation and permeability.

Area of Science:

  • Cell biology
  • Vascular biology
  • Biochemistry

Context:

  • Endothelial cell-cell junctions are crucial for maintaining the integrity of the vascular system.
  • These junctions, analogous to epithelial junctions, include tight junctions, adherens junctions, gap junctions, and complexus adherentes.
  • Recent advancements have elucidated the molecular components and interactions within these endothelial junctions.

Purpose:

  • To review the molecular components and interactions of endothelial cell-cell junctions.
  • To discuss the role of these junctions in linking the cell membrane to the cytoskeleton.
  • To explore the contribution of endothelial junctions to vessel formation and permeability.

Summary:

  • Endothelial cell-cell junctions are complex structures essential for vascular integrity.

Related Experiment Videos

  • The molecular players and their interactions within these junctions have been identified, clarifying the cell membrane-cytoskeleton connection.
  • This review synthesizes current knowledge on the function of these junctions in angiogenesis and vascular permeability.

    • Impact:

    • Provides a comprehensive overview of endothelial junction biology.
    • Highlights the molecular mechanisms underlying vascular integrity and function.
    • Offers insights into potential therapeutic targets for vascular diseases.