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Effect of clomifene on thyroid function in normal men.

U Feldt-Rasmussen, A P Lange, J Date

    Acta Endocrinologica
    |January 1, 1979
    PubMed
    Summary
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    Clomifene citrate administration in healthy males caused slight but significant changes in thyroid function, including decreased triiodothyronine and altered thyroid-stimulating hormone (TSH) response to TRH.

    Area of Science:

    • Endocrinology
    • Pharmacology

    Background:

    • Clomifene citrate is primarily known for its effects on reproductive hormones.
    • Its potential impact on thyroid function in males is less understood.

    Purpose of the Study:

    • To investigate the effects of clomifene citrate on thyroid function in healthy male volunteers.
    • To assess changes in thyroid hormones, TSH, and TSH response to TRH.

    Main Methods:

    • Two groups of healthy males received 100 mg clomifene citrate daily for 5 or 12 days.
    • Serum levels of TSH, thyroxine, triiodothyronine, and thyroid hormone binding proteins were measured.
    • Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were assessed in one group.
    • TSH response to TRH stimulation was evaluated in the second group.

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    Main Results:

    • Clomifene increased FSH and LH levels significantly.
    • A small, statistically significant decrease in triiodothyronine and free thyroxine index was observed.
    • A slight increase in TSH was noted on day 5.
    • TSH response to TRH significantly increased after 12 days of clomifene, returning to normal after discontinuation.

    Conclusions:

    • Clomifene citrate exerts a direct influence on thyroid function in males.
    • Observed thyroid function changes, though slight, warrant consideration.