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Updated: Aug 1, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
[Trans-meatal hyperbaric aerosol therapy some forms of otitis media chronica]
Abstract:
80 patients with otitis media chronica were effectively treated with hyperbaric aerosol. The aerosol therapy was performed with the help of a special device the design of which was based on that of made in Russia ultrasonic inhalator IUP-OIM intended for aerosol therapy of the upper respiratory tracts. The inhalator was furnished with a mini-compressor for pumping aerosol in the middle ear with maximal permissible pressure of hyperbaric aerosol delivery 10 kPa. Such intratympanic pressure rules out the risk of ear barotrauma in the form of the cochlear window membrane rupture being at the same time sufficient for aerosol delivery into the nasopharynx through the mesotympanic defect of the tympanic membrane and the auditory tube, in secretory otitis--via previously made tympanostoma. The method provides also normobaric delivery of aerosol into the ear and therefore can be applied after tympanoplastic operations without the risk of the transplant dislocation.
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