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Amino acid metabolism in liver disease
1Department of Pathophysiology, Medical Clinic I Mannheim, University of Heidelberg, Germany. eggert.holm@urz.uniheidelberg.de
Current Opinion in Clinical Nutrition and Metabolic Care
|August 24, 1999
Abstract:
The impairment of transsulphuration during methionine degradation in hepatic failure can be counteracted by treatment with S-adenosylmethionine. Regarding the pathogenesis of hepatic encephalopathy, no convincing evidence exists for tryptophan, glutamine or glutamate being involved. Portal-systemic shunting-induced hyperammonaemia may reduce plasma branched-chain amino acids. The glucose effect on urea synthesis does not exist in cirrhosis.