[Relationship between the activity of leukocyte chemokines in gingival crevicular fluid and periodontitis]

Chemotactic activity in gingival crevicular fluids (GCF) from 39 cases of patients with periodontitis and 10 cases of healthy donors was determined via Boyden method.

Chemotactic activity in GCF from patients was much higher than that from healthy donors. Chemotactic activity in GCF was not relative to pocket depth and attachment loss, but markely correlative to gingival index and bleeding index.

The results indicates that leukocyte chemokine activity would not reflect the degree of periodontal damage, but might be a marker for periodontal inflammatory reaction and disease activity. It is likely that interleukin-8 might be a major component among the chemokines in GCF.