Dental abnormalities as long-term effects in pediatric patients with leukemia: A scoping review
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Published on: March 29, 2018
V-F-S Filho1, L-R da Motta, J-K Ribeiro
1Valder Ferreira da Silva Filho Faculty of Dentistry Faculdade Sete Lagoas (FACSETE) Street Itália Pontelo, 50/86 - Chácara do Paiva, Sete Lagoas - MG, 35700-170, Brazil valder.filho1@outlook.com.br.
Background:
The aim of this scoping review is to analyze the existing evidence on the long-term effects of dental abnormalities in pediatric patients with leukemia.
Materials And Methods:
A scoping review was conducted and followed the Preferred Reporting Items for Systematic Review and Meta-Analysis with extension for scoping reviews. The review was registered in Open Science Framework, under registration number DOI: 10.17605/OSF.IO/XKP6U. Two independent reviewers conducted searches in MEDLINE (via PubMed), Embase, Web of Science, Scopus, Web of Science, and LILACS, and Google Scholar for grey literature. The critical evaluation of the included studies was done with Oxford-CEBM Levels of Evidence for intervention questions.
Results:
Of the 565 potentially eligible articles for selection, 27 were included. The most frequently observed alterations included microdontia, enamel defects, dental agenesis, and root abnormalities such as shortening, tapering, and arrested development. Younger age at the time of treatment was consistently associated with increased severity of these alterations.
Conclusions:
The evidence indicates that antineoplastic therapy during childhood is associated with a wide range of long-term dental abnormalities, particularly when treatment occurs during early stages of odontogenesis. Further robust studies should be conducted aiming to confirm it.
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