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Updated: Oct 19, 2026
Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
Published on: September 23, 2015
Serotonin depolarizes hippocampal interneurones in the rat stratum oriens by interaction with 5HT2 receptors
K Lee1, A K Dixon, R D Pinnock
1Parke-Davis Neuroscience Research Centre, Cambridge University Forvie Site, UK. kevin.lee2@wl.com
Abstract:
Patch-clamp recording techniques were used to examine the effect of serotonin (5HT) upon interneurones contained in the stratum oriens layer of hippocampal slices. Bath application of 1-20 microM 5HT depolarized neurones by the induction of an inward current at -60 mV. This inward current was Na+-dependent in nature, was mimicked by the 5HT2 receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and was inhibited by pre-incubation with the 5HT2 receptor antagonist ritanserin.
