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Seizures following renal transplantation in childhood

A Q Awan1, M A Lewis, R J Postlethwaite

  • 1Department of Nephrology, Royal Manchester Children's Hospital, Pendlebury, UK.

Pediatric Nephrology (Berlin, Germany)
|August 24, 1999
PubMed

Insights

Seizures are common after pediatric kidney transplants, affecting 21 of 119 procedures. Key risk factors include hypertension, infection, and rejection, with most cases having good neurological outcomes.

Area of Science:

  • Pediatric Nephrology
  • Pediatric Neurology
  • Transplantation Immunology

Background:

  • Limited research exists on seizure incidence post-pediatric renal transplantation.
  • Understanding seizure prevalence and risk factors is crucial for managing pediatric transplant recipients.

Purpose of the Study:

  • To determine the incidence of seizures following renal transplantation in children.
  • To identify specific risk factors associated with post-transplant seizures in this population.

Main Methods:

  • Retrospective analysis of 119 renal transplants in 109 children over a 10-year period.
  • Case notes were reviewed to identify seizure occurrences and associated clinical data.

Main Results:

  • Seizures complicated 21 transplants (17.6%) in 20 children, predominantly within 55 days post-transplant.
  • The 5- to 10-year age group showed a higher incidence of seizures (P=0.03).
  • Hypertension (n=15), fever/infection (n=4), and acute allograft rejection (n=6) were identified as common risk factors.

Conclusions:

  • Seizures are a relatively common complication after pediatric renal transplantation.
  • While multifactorial, hypertension and acute rejection are significant risk factors.
  • Most seizures were transient with favorable long-term neurological outcomes, and parental counseling is now standard practice.

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