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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Structural requirement of the calcium-channel subunit alpha2delta for gabapentin binding

M Wang1, J Offord, D L Oxender

  • 1Department of Molecular Biology, Parke-Davis Pharmaceutical Research Division of Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, MI 48105, USA.

The Biochemical Journal
|August 24, 1999
PubMed
Summary

Gabapentin binding to the alpha(2)delta subunit requires both alpha(2) and delta subunits. Specific regions within the alpha(2) subunit, particularly Arg(217), are critical for this interaction.

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