Related Experiment Videos
Cross-resistance with dieldrin of a novel tricyclic dinitrile GABA receptor antagonist
K Matsuda1, A M Hosie, C W Holyoke
1The Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, USA.
British Journal of Pharmacology
|August 24, 1999
Abstract:
A novel tricyclic dinitrile, KN244, blocked the wild-type (dieldrin-sensitive) homo-oligomeric gamma-aminobutyric acid (GABA)-gated chloride channel of Drosophila melanogaster expressed in Xenopus oocytes. Sensitivity to the block by KN244 of the response to 30 microM GABA (IC50=41.6 nM, wild-type RDLac) was reduced abut 100 fold (IC50=4.5 microM) in the dieldrin-resistant (RDLacA302S) form of RDL.