Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microchimerism: implications for autoimmune disease.

J L Nelson1

  • 1Program in Human Immunogenetics, Fred Hutchinson Cancer Research Center, and Rheumatology, University of Washington, Seattle 98109-1024, USA.

Lupus
|August 24, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Umbilical Cord Maternal Microchimerism in Normal and Preeclampsia Pregnancies.

Reproductive sciences (Thousand Oaks, Calif.)·2022
Same author

Fetal microchimerism by mode of delivery: a prospective cohort study.

BJOG : an international journal of obstetrics and gynaecology·2018
Same author

Effect of oral nutritional supplementation on wound healing in diabetic foot ulcers: a prospective randomized controlled trial.

Diabetic medicine : a journal of the British Diabetic Association·2014
Same author

Dermatological compounds from the Caribbean.

International journal of pharmaceutical compounding·2013
Same author

Prospective assessment of fetal-maternal cell transfer in miscarriage and pregnancy termination.

Human reproduction (Oxford, England)·2012
Same author

Dynamic changes in fetal microchimerism in maternal peripheral blood mononuclear cells, CD4+ and CD8+ cells in normal pregnancy.

Placenta·2010
Same journal

An evidence-based specialist nursing protocol for children with hypoprothrombinemia-lupus anticoagulant syndrome (HLAS) and its application research.

Lupus·2026
Same journal

T-bet expression in B cell subsets: Association with T peripheral helper cells and clinical activity in systemic lupus erythematosus.

Lupus·2026
Same journal

Autonomic dysfunction in systemic lupus erythematosus and systemic sclerosis.

Lupus·2026
Same journal

Recent advances in the management of pediatric neuropsychiatric lupus from conventional therapies to novel immunomodulators.

Lupus·2026
Same journal

Association of serum and urinary galectin-3 with renal fibrosis in patients with lupus nephritis: A cross-sectional controlled study.

Lupus·2026
Same journal

Continuation of belimumab in patients with systemic lupus erythematosus in a real-world setting: A single-center retrospective cohort study.

Lupus·2026
See all related articles

Fetal cells can persist in mothers for decades, leading to microchimerism. This phenomenon may play a role in autoimmune diseases, though further research is needed to confirm its involvement in disease pathogenesis.

Area of Science:

  • Immunology
  • Reproductive Biology
  • Genetics

Background:

  • Cells can transfer between mother and fetus during pregnancy.
  • Fetal cells can persist in maternal circulation for many years post-childbirth.
  • This long-term fetal cell presence is termed microchimerism.

Purpose of the Study:

  • To explore the hypothesis that microchimerism is involved in autoimmune diseases.
  • To investigate potential sources of microchimerism beyond pregnancy.
  • To understand the role of microchimerism in disease pathogenesis.

Main Methods:

  • Review of existing studies on cell trafficking and microchimerism.
  • Analysis of clinical similarities between microchimerism and autoimmune conditions.
  • Consideration of non-pregnancy related sources of engraftment.

Related Experiment Videos

Main Results:

  • Fetal cells are known to persist in mothers long-term.
  • Microchimerism is observed in healthy individuals and may be acquired through various means.
  • Initial evidence supports a link between microchimerism and autoimmune diseases.

Conclusions:

  • Microchimerism is a common finding with potential implications for autoimmune diseases.
  • Further research is required to establish a causal role for microchimerism in disease pathogenesis.
  • Understanding microchimerism could pave the way for novel therapeutic strategies.