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Autistic regression with rolandic spikes.

R Nass¹, O Devinsky

¹New York University Medical Center, Department of Neurology, NYC 10016, USA. rn7@IS2.NYU.EDU

Neuropsychiatry, Neuropsychology, and Behavioral Neurology

|August 24, 1999

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Landau-Kleffner syndrome variants present with centro-temporal spikes and autistic epileptiform regression. This differs from typical Landau-Kleffner syndrome, impacting expressive language more than receptive language.

Area of Science:

Neuroscience
Epileptology
Developmental Neuroscience

Background:

Landau-Kleffner syndrome (LKS) is a rare disorder characterized by acquired epileptic aphasia.
Putative variants of LKS are more frequently encountered than the classic form.

Observation:

Two patients presented with centro-temporal spikes, autistic epileptiform regression, and oro-motor symptoms.
Electroencephalographic abnormalities were analyzed in relation to clinical features.

Findings:

Patients with prominent Rolandic spikes exhibited an epileptic aphasia pattern more frequently affecting expressive language.
This contrasts with typical LKS, where verbal auditory agnosia (receptive language impairment) is predominant.

Implications:

Related Experiment Videos

The location of epileptiform activity (centrotemporal vs. anterior/mid-temporal) influences the specific language deficits observed.
Understanding these variants is crucial for accurate diagnosis and targeted therapeutic strategies in pediatric epilepsy and language disorders.