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Morphological observation of canine natural killer cells mediated cytotoxicity
Y Nariai Nakada1, K Nariai, T Kosaka
1Laboratory Animal Facility, School of Medicine, Yokohama City University, Yokohama, Kanagawa, Japan.
The Journal of Veterinary Medical Science
|August 24, 1999
Abstract:
The cytotoxic effects of canine NK cells on CL-1 target cells were examined by scanning electron microscopy (SEM). NK cell mediated cytotoxicity on CL-1 target cells was detected by 51Cr release assay. SEM showed that a canine NK cell extended projections to the CL-1 target cell. Furthermore, the surface of CL-1 target cells changed a mesh-like structure. Therefore, the cytotoxic effects of canine NK cells on CL-1 target cells were morphologically demonstrated.