[Combined treatment of acute diffuse peritonitis]

Area of Science:

• Medicine
• Surgery
• Intensive Care Medicine

Background:

• Acute diffuse peritonitis is a severe condition with high mortality.
• Conventional treatment methods alone have limitations in improving outcomes.

Purpose of the Study:

• To evaluate the effectiveness of novel treatment strategies for acute diffuse peritonitis.
• To compare outcomes between conventional treatment, plasmapheresis, and combined therapies.

Main Methods:

• A comparative study involving 199 patients with acute diffuse peritonitis.
• Group 1: Conventional treatment.
• Group 2: Conventional treatment + exchange plasmapheresis.
• Group 3: Conventional treatment + extracorporeal detoxication and elective relaparotomies.

Main Results:

• Lethality rates were 39% (conventional), 29% (plasmapheresis), and 24.5% (combined).
• Exchange plasmapheresis and combined therapy demonstrated increased treatment effectiveness.
• Treatment intervals were adjusted based on peritonitis stage and progression.

Conclusions:

• Exchange plasmapheresis and combined therapy significantly reduce lethality in acute diffuse peritonitis.
• These advanced methods offer improved therapeutic outcomes compared to conventional treatment alone.