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p190 BCR-ABL rearrangement in chronic myeloid leukemia and acute lymphoblastic leukemia
A Lemes1, M T Gómez Casares, S de la Iglesia
1Servicio de Hematología, Hospital Universitario Na Sra. del Pino, Las Palmas de Gran Canaria, Spain.
Abstract:
A minority of chronic myeloid leukemia (CML) cases have breakpoint in the minor cluster region (m-bcr) of the BCR-ABL fusion gene. We report a patient with Ph-positive acute lymphoblastic leukemia and m-bcr breakpoint at diagnosis. The patient was treated with chemotherapy followed by an autologous peripheral blood stem cell transplantation, achieving a clinical and hematological complete remission but with persistence of the Philadelphia chromosome. One year later, she developed leukocytosis with a blood picture consistent with CML. She was treated with hydroxyurea and interferon alpha with no response. This is the second case of m-bcr CML reported presenting with features of lymphoid blast crisis or acute lymphoblastic leukemia.