Related Experiment Video
Updated: Aug 10, 2026
06:51
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
Hepato-biliary abnormalities secondary to ceftriaxone use: a case report
1Mid-Florida Medical Services, Haines City 33844, USA.
The Journal of the Oklahoma State Medical Association
|August 26, 1999
Summary
Ceftriaxone, approved in 1997, can cause biliary stasis and elevated liver enzymes, particularly in children with a family history of gallbladder issues. Physicians need awareness regarding these risks when prescribing this antibiotic.
Area of Science:
- Pharmacology
- Hepatology
- Pediatrics
Background:
- Ceftriaxone, a third-generation cephalosporin antibiotic, was approved in 1997.
- Previous studies indicated potential associations between ceftriaxone use and elevated hepato-biliary enzymes and transient biliary stasis.
Observation:
- A case highlights the need for physician awareness regarding ceftriaxone's adverse effects.
- Ceftriaxone is frequently prescribed for common pediatric infections like otitis media and acute exudative tonsillitis.
Findings:
- Ceftriaxone use is linked to elevated hepato-biliary enzymes and transient biliary stasis.
- Children with a family history of gallbladder, biliary tract, liver, or pancreas dysfunction are at increased risk of complications.
- Pre-existing conditions, malnutrition, or dehydration can exacerbate ceftriaxone-related issues in both children and adults.
Implications:
- Continued medical education is crucial for physicians prescribing ceftriaxone.
- Alternative antibiotic choices may be warranted for at-risk pediatric populations.
- Careful patient selection and monitoring are essential to mitigate ceftriaxone-induced hepato-biliary complications.
More Related Videos
Related Concept Videos
01:17Chronic Bowel Disorders: Introduction
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:26Diseases of the Liver and Gallbladder
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
01:27Acute Pyelonephritis I: Introduction
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
01:20Cholecystitis
Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...